In the first study of its kind, researchers at RCSI University of Medicine and Health Sciences and the Rotunda Hospital, Dublin have shown that it is safe for first-time mothers to spend the first 24 hours of induced low-risk labour in the comfort of their own homes.

The RCSI-Rotunda HOME INDUCTION study examined what happens when first-time mothers choose to have labour induced as an outpatient at 39 weeks and then return home to wait for labour to start. 

The findings, published in the prestigious medical journal The Lancet (eClinicalMedicine), show that the mothers’ experiences are generally positive, and that there are no additional risks for the birth. The ground-breaking research can now pave the way for first-time mothers to have a more satisfactory induction of labour while reducing the pressure on busy maternity services. 

“Induction of labour at 39 weeks’ gestation has been shown to be safe and effective for first-time mothers, and it minimises the chances of Caesarean section while maximising safety for mother and baby, and if mothers would like to start the process of induction in an outpatient setting, it could help to alleviate the pressure on busy maternity hospitals,” explains study lead-author Professor Fergal Malone, Professor of Obstetrics and Gynaecology at RCSI and Consultant in Obstetrics and Gynaecology at the Rotunda Hospital. 

“But until now, there has been minimal data available to guide mothers, midwives and obstetricians on how safe and effective it is to start the induction of labour as an outpatient.” 

The RCSI-Rotunda HOME INDUCTION study was a randomised trial that compared methods of induction at 39 weeks in the outpatient setting for 271 normal-risk first-time mothers. Each mother had labour induced as an outpatient, either with a prostaglandin gel or a device that dilates the cervix, then went home for 12-24 hours before returning to the hospital to have the baby.   

Safe and effective

The study showed that both induction approaches were safe and effective in the outpatient setting. Three-quarters of the mothers in the study successfully delivered their babies vaginally – which meant there was no increased risk of Caesarean delivery compared to women who choose to continue their pregnancy – and patient surveys demonstrated very high levels of patient satisfaction on the study. 

The research builds on the proven benefits of elective 39-week induction of labour for first-time mothers and will enable patients and their doctors or midwives to choose the optimal induction method that suits their needs. 

“Given that more and more patients are now choosing induction of labour, this is causing challenges for busy maternity hospitals which struggle to manage these large patient numbers while trying to optimise patient comfort and safety. Outpatient induction of labour is an emerging system that might enable larger numbers of patients to choose induction if that is their preference, while remaining in the comfort of their own home,” says Professor Malone.  

“The results of our study can now be used by pregnant women, midwives, obstetricians and hospital managers to make rational, evidence-based decisions on how to optimise their delivery experience, providing high rates of vaginal delivery, with excellent patient safety and high degrees of patient satisfaction. In our desire to support patient choice, this study optimises the information that is available to patients so that they can help design the best delivery plan that suits their needs.” 

The RCSI-Rotunda HOME INDUCTION study was carried out by the RCSI Department of Obstetrics and Gynaecology, RCSI School of Pharmacy and Biomolecular Sciences and RCSI School of Population Health and was supported by unrestricted grants from Medicem Technology s.r.o and The Rotunda Foundation. 

The study’s findings are published in The Lancet (eCLinicalMedicine): ‘Outpatient elective induction of labour at 39 weeks’ gestation (HOME INDUCTION): An open-label, randomised, controlled, phase III, non-inferiority trial.’